The FAP Gene Support Group
(Familial Adenomatous Polyposis)
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In 2008 we started to explore curcumin to control the colonic polyp in our 14 year old son's Familial Adenomatous Polyposis in our desire to delay surgery for as long as possible. Our first hope was for him to reach age 18 to allow him to make his own decision regarding medical intervention which gave him time to study for his GCSE exams without interruption from surgery and following recovery.
Back in 2008, as a minor at age 14, understandably there was pressure from the medical department for immediate surgery to take place. A polyp count of 150 plus would have him at risk as the FAP polyps can escalate in an unpredictable manner, therefore we went about to present to the NHS evidence based research papers of curcumin safety in humans, along with other studies which showed curcumin having a positive effect upon the biological pathways that will slow down polyp development. With the Oxford genetic department, satisfied safety was evident and they agreed to support a 9 month trial period of curcumin use with a colonoscopy at the end of that period. Following the 9 months of curcumin, the polyps remained stable so it was agreed for the curcumin evaluation to be extended a following 12 months, with this now the general procedure for all three following our 2nd son and daughter now joining the trial with their fist colonoscopy evaluation in 2010.
Here in 2016, all three still continue to take curcumin as it seemingly does manage their polyps for they have not needed surgery up to 2016.
Regards the curcumin dose, this has been raised from
a low dose of 1-2g in 2008, to now a dose of 12g a day in 2016 with adjustment
needing in a age related polyp increase. We have noted that from age 16
the polyps expression seem to increase dramatically needing a higher dose
of curcumin of 8g a day by the age of 18years.
In our second son, now aged 21, we tried combining curcumin
with highly concentrated EPA fish oil called 'Alfa capsules' supplied
by SLA Pharma from 2012 to 2015. The results had shown some promise, yet
unfortunately the supply of Alfa Capsules became to intermittent so to
allow a continued and fair evaluation of results.
Below is a basic chart of results, with columns
giving the year of the scope; the polyp results that year; the age of
the person; and what dose was used over the 12 months to give the results.
FAP Gene would like to thank Peter and his family for the information in this update.