The FAP Gene Support Group

(Familial Adenomatous Polyposis)

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FAP Gene Support Group Duodenal Polyps

The early part of 2018 has seen an increase in the number of requests for information on Duodenal Polyps. Information received by patients with FAP has been very varied and so confusing. We do however accept that the views of consultants can differ and that not all cases are the same.

We have decided to try and improve the information available by giving links to respected articles from reliable sources. These will open in a new page.

Gut is a leading international journal in gastroenterology and hepatology and has an established reputation for publishing first class clinical research of the alimentary tract, the liver, biliary tree and pancreas. Gut delivers up-to-date, authoritative, clinically oriented coverage in all areas of gastroenterology and hepatology. Regular features include articles describing novel mechanisms of disease and new management strategies, both diagnostic and therapeutic, likely to impact on clinical practice within the foreseeable future by leading authorities.

Familial adenomatous polyposis (FAP) is one of two well described forms of hereditary colorectal cancer. The primary cause of death from this syndrome is colorectal cancer which inevitably develops usually by the fifth decade of life. Screening by genetic testing and endoscopy in concert with prophylactic surgery has significantly improved the overall survival of FAP patients. However, less well appreciated by medical providers is the second leading cause of death in FAP, duodenal adenocarcinoma. This review will discuss the clinicopathological features, management, and prevention of duodenal neoplasia in patients with familial adenomatous polyposis. Link to article